1novels #502 - Side Breakthrough
#502 - Side Breakthrough
After basically settling the aviation industry, Ren Zhong turned his attention to the pharmaceutical industry.
In the world of "Bright Sword", the Dongda Pharmaceutical Industry, starting with penicillin, was not weak. Under Ren Zhong's care, by firmly controlling the patent technology authorization for penicillin and its derivatives, this drug for treating various bacterial infections became the best-selling pharmaceutical product in the "Bright Sword" world.
The huge output from direct sales and the high patent fees from authorization allowed Dongda Pharmaceutical to become one of the world's top ten pharmaceutical companies based solely on this product.
However, Ren Zhong didn't let Dongda's pharmaceutical industry stop there. After penicillin, he obtained the manufacturing process data for another important drug, vidarabine, from the main world. He gave this information to the Pharmaceutical Research Center, asking them to research and replicate the complete and detailed production process of this broad-spectrum antiviral drug in the world of "Bright Sword".
Although many methods for preparing this drug can be found in the main world, such as the two most classic production methods:
Method 1: Using 5'-adenylic acid (5'-AMP) as raw material, it undergoes selective tosylation, hydrolytic dephosphorylation, bromination, and acetylation to obtain 8-hydroxy-N,3',5'-O-triethyl-2'-O-tosyladenosine. It is cyclized in methanol-ammonia, then ring-opened in methanol-hydrogen sulfide to obtain 8-mercaptovidarabine, which can be hydrogenated to remove sulfur to obtain vidarabine.
5'-Adenylic acid [p-toluenesulfonyl chloride] → 2'-O-tosyladenosine-5'-monophosphate [ammonia, formamide] → 2'-O-tosyladenosine [Br2] → 8-bromo-2'-O-tosyladenosine [acetic acid, acetic anhydride] → 8-hydroxy-N, 3', 5'-O-triethyl-2'-O-tosyladenosine [methanol ammonia] → 8, 2'-O-cycloadenosine [methanol-hydrogen sulfide] → 8-mercaptovidarabine [Raney nickel] → vidarabine
Method 2: Using uridine as raw material, it is first reacted with phosphorus oxychloride and dimethylformamide, then hydrolyzed under alkaline (pH = 9) conditions to obtain ara-uridine. After hydrolysis by pyrimidine nucleoside phosphorylase at a temperature of 60℃, uracil is removed to obtain ara-1-phosphate, which is catalyzed by purine nucleoside phosphorylase and condensed with adenine at 60℃ to obtain vidarabine.
Uridine [phosphorus oxychloride, dimethylformamide] → [pH9] ara-uridine [pyrimidine nucleoside phosphorylase] → ara-1-phosphate [purine nucleoside phosphorylase] → vidarabine.
Even though Ren Zhong tried his best to collect relevant information from the main world, these were still mostly principle-level methods. He couldn't find any process standards from the preparation of process equipment to intermediate mass production. It could only be said that the technical route direction was correct, but it was far from enough for mass production.
Therefore, based on the preparation process data provided by Ren Zhong, the Pharmaceutical Research Center had to do both process design and mass production research. Although it reduced the time cost of countless trial-and-error technical branches, it still took the Pharmaceutical Research Center four or five years of overtime work to complete the preliminary preparation process method and start small-batch production. After 3/4 years of clinical trials, it was not easy to complete the verification of various clinical effects in the world of "Bright Sword" in 1959 and enter the mass production application stage.
Yandu, Dean's Office of the Dawn Research Institute.
"Dean Ren, our new drug has now completed Dongda's drug clinical trials and is ready for mass production. Now we need to choose a name. The comrades all said that it was completed with the ideas provided by Dean Ren, so it is appropriate for Dean Ren to name it." Professor Mu Senlin, the head of the Pharmaceutical Research Center, handed the report to Ren Zhong very respectfully.
Ren Zhong took the report and simply looked at the conclusion. After clinical trials, this drug has significant effects in treating viral diseases such as chronic hepatitis B, herpes simplex viral encephalitis, herpes zoster, genital herpes, neonatal herpes simplex infection, varicella in immunocompromised patients, herpes zoster infection, herpetic myelitis, keratitis and iridocyclitis, cytomegalovirus pneumonia, as well as diseases such as angina pectoris, myocardial infarction, coronary insufficiency, arteriosclerosis, primary hypertension, cerebrovascular disorders, sequelae of stroke, and progressive muscular atrophy.
These were all treatable diseases provided by Ren Zhong, so naturally, clinical trials had to be carried out one by one. Fortunately, Ren Zhong also provided a short list of disease names, which allowed the research work to be targeted and the clinical trials to be completed in just a few years.
"Not bad, Professor Mu, your work has been very effective. With the advent of this drug, Dongda Pharmaceuticals will have another trump card." Ren Zhong said to Professor Mu Senlin after simply reading the report, "As for the name of the drug,"
Ren Zhong thought for a while before looking up and saying, "Since the main function of our drug is antiviral, I think it should be called Virus Clear Injection, and the English name should be Broad-spectrum antiviral, which is also true to its name."
The absorption effect of this drug is not good whether it is taken orally, intramuscularly, or subcutaneously. The best way is intravenous drip, so the drug is mainly in the form of injection.
"Good name, Virus Clear, Broad-spectrum antiviral injection are both good names!" Professor Mu responded with praise. "Then we will use these two names for registration."
These were all trivial matters. Next, a series of tasks such as trademark registration and patent application for confidential processes were handled specially and very quickly. During this period, Dongda Pharmaceutical's production line was also completed. After the intellectual property matters were implemented, the first batch of mass-produced drugs began to supply Dongda's domestic hospitals and began large-scale clinical applications.
For the vast number of patients suffering from viral infections, the advent of Virus Clear greatly alleviated the suffering of patients. Many patients quickly achieved therapeutic effects after using this drug. After a short half-year of large-scale clinical application, the overall therapeutic effect of this drug once again shocked the world medical community!
After short-term clinical trials and data exchange, the European side approved this drug very quickly. Nowadays, relying on the good relationship between Dongda and John Bull, as well as Dongda's long-term operation in other European countries, Dongda's drugs can also enjoy special channels to pass the European drug inspection standards and begin to obtain the right to sell in Europe.
In this way, broad-spectrum antiviral injection pharmaceutical products quickly became another cash cow for Dongda Pharmaceutical!
However, at this time, disharmonious voices came out again.
Although the team was somewhat surprised by Ren Zhong's reaction this time, they faithfully carried out his instructions.
They didn't know that, in terms of broad-spectrum antiviral drugs, there was nothing better than Dongda's drug in this timeline. Just like penicillin, the efficacy of this drug was unique!
Ren Zhong was waiting for the North American patients to understand the efficacy. He didn't believe they could remain indifferent!
This time, Ren Zhong didn't plan to have Dongda negotiate and compromise with the other party through official channels. Instead, he intended to use the hands of North American patients to teach the FDA a good lesson.
Houston.
"Mark, Little Willie's shingles infection hasn't improved for several weeks. It's really worrying," a young mother said, looking at her 5-year-old son with a worried expression.
Mark, who was next to her, was reading the newspaper. Suddenly, he saw an amazing piece of news.
"Viral diseases have been conquered! Broad-spectrum antiviral injection developed!" Below this science and technology news was a comparison of the therapeutic effects of multiple drugs on more than a dozen viral diseases from Europe. According to the data, a broad-spectrum antiviral injection from Dongda was several times more effective than traditional treatments, almost a specific drug for viral diseases!
"Mary, don't worry, there's a specific drug for Little Willie's illness. Tomorrow, we'll ask the doctor where we can buy this broad-spectrum antiviral injection. If we use such a specific drug, Little Willie can recover in a few days."
As Mark spoke, he handed the newspaper to his wife, Mary, pointing to the part comparing the therapeutic effects of the disease. "Look, the cure rate for shingles is over 95%! Heavens, this broad-spectrum antiviral injection is too magical."
Manhattan.
Nick, who lived in a single apartment, was fed up with his unspeakable problem.
As an open-minded and heterosexual man in a world of dazzling pleasures, his 'little head' was often difficult to control. After wandering through the flowers too much, he inevitably got caught. The genital herpes he contracted three months ago had been tormenting him for so long without any improvement. The damn doctor only told him to be self-disciplined to avoid this disease, but never thought about how to cure it.
He opened the Starry Sky TV channel with a sense of hopelessness and happened to see a news report about European hospitals treating herpes. It said that since the introduction of the broad-spectrum antiviral injection, the cure rate for herpes treatment in Europe had reached over 95%! With the broad-spectrum antiviral injection, all kinds of herpes were no longer a problem!
"Shit, damn doctor, they have such good medicine but are reluctant to use it on me! Does my health insurance only deserve to be used by the rich?" Nick couldn't help but curse at the TV. He secretly resolved to make the doctor prescribe such a specific drug for his treatment tomorrow, no matter what.
The latest novels are first published on 69书吧!
However, when these patients excitedly rushed into the hospital, demanding to use this latest specific drug for their treatment.
Every doctor told them very regretfully, "Yes, we noticed that there is this antiviral specific drug, but we are very sorry, this specific drug has not been approved by the FDA yet, so it cannot be imported. Currently, it is only sold in European and Dongda countries and regions."
Coming excitedly and returning disappointed, the sense of loss was too great for patients who came full of hope.
However, these things were beyond their control. People who were tormented by the disease and had no way out began to try to go to Europe for treatment, rushing to use this specific drug.
Thousands of smart patients verified the effectiveness of this specific drug through medical treatment trips and transmitted this information back to hundreds of thousands of similar patients in North America. Some of these people had economic factors or other reasons that prevented them from traveling across the ocean to use this specific drug for treatment. Some gray gangs saw this opportunity and began to try to import some goods from Europe, secretly bringing them into North America and using them for the poor North American patients at prices 3 to 5 times higher.
Over time, everyone discovered that something was wrong. How could this specific drug not pass the FDA certification process even after it had cured tens of thousands of patients among the people, causing this specific drug to be impossible to formally introduce into North America?
Some curious reporters discovered this problem and began to secretly investigate. The results made them extremely angry. The FDA was simply perfunctory in the certification work of this specific drug. They did not carry out the certification of this specific drug according to normal procedures, but repeatedly asked the other party to provide various materials!
In terms of the process, it was equivalent to indefinitely delaying the certification of this medicine.
When reporters exposed such news through newspapers and television media, the public's anger was ignited at once!
Initially, only some patients and their families began to denounce the FDA's chaotic behavior in newspapers and television interviews. Then, patients like Nick began to jump out and take to the streets, holding signs and shouting!
Soon, more and more patients who understood this matter began to take to the streets to support Nick's appeals. From hundreds of people, thousands of people, and several cities, it slowly developed into a joint petition action of tens of thousands of people in dozens of cities. This kind of gathered, tsunami-like pressure directly scared the people in the FDA to pee!
They never thought that taking a little benefit from pharmaceutical giants and doing a small matter of certifying a pharmaceutical company according to the usual practice would turn into such a large group incident.
It was as if they had stirred up a hornet's nest, turning the FDA into a rat crossing the street that everyone shouted to beat. Now, even going out would be met with being thrown rotten eggs and tomatoes.
Now they didn't dare to do any more tricks and began to urgently meet with Dongda Pharmaceutical to start the formal process. However, at this time, Dongda Pharmaceutical, which was watching the fire from the other side of the river, was not panicked.
They calmly enjoyed the special treatment of being fully escorted through the certification process at their own pace. On this matter, only a very few high-level executives of Dongda Pharmaceutical knew that the exposure of many media news was for a reason.
This was the first time Ren Zhong used the media seeds he had planted to help Dongda.
From the results, the effect was much better than formal government negotiations.